barrier function
Maintain homeostasis
by constant recycling of the basal cell layer
Dermis
Fibroblasts
Constitutes the bulk of the skin
Composed of collagen with elastin
and glycosaminoglycans (GAG’s)
major role in the biomechanics of the skin
Hypodermis
Adipose tissue (vascularized, connective tissue)
Contributes to both the thermoregulatory
Shoo
■ Objectives of Defense-in-Depth
• To compensate for potential human and component
failures
• To maintain the effectiveness of the barriers by averting
damage to the facilities and to the barriers themselves
• To protect the public and the environment from harm in
the event that those barriers are not fully effective
■ Strategy of
Neurophysiological property
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s.
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm o
afferent C-fiber
diversity of cutaneous n.s
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Immunological abnormality
T cell defect
CD8 suppressor/cytotoxic T cell↓
↑IL-4, ↓IFN-γ
Induce CD23(low-affinity IgER) on B cells
Increased IgE synthesis
Sustained T cell activation
STEP1: ABOUT SKIN CANCER
Cause of cancer _ 2 cases
1.Cell growth doesn’t stop
2.Disorder of apoptosis
p53 : Tumor repressor gene
P53 : transcription factor
Functions
-p53 are that first arrest cell cycle so control cell growth, also active apoptosis suicide program
P53 mutation ->p53 sytem breaks down, it can’t act as Transcriptor factor-> generating tumor
ghetto, refugee, or natural disaster situations.
Supporting data
코흐트 연구 결과
신선한 과일과 채소 섭취 : TB의 상대위험도를 0.4까지 낮춤 (채식주의자는?)
Vitamin A, vitamin C, protein의 영향력
body mass index(BMI), average skin-fold thickness, upper arm muscle : hazard of TB from six to ten fold
동물 실험 모델 : Zinc, Vitamin D, protein
(1) function : line of defense to protect our body
(2) skin is classified to lung
(3) Distinguish Disease with skin color
Disease : acne on face, especially cheek
Facial color : white and have a light red
Attack stage : acne moved forehead to cheek from 2 years ago.
Attack inducement
irregular eating habit
having a taste with instant food.
stress
Personality Disorders Characterized by Dramatic, Emotional, or Erratic Behavior
1. Antisocial Personality Disorder(반사회적 성격장애)
→ 타인의 권리를 무시하거나 또는 침해의 광범위한 행동 양식이 나타나는
것을 의미함
→ 대개 충동적이고 다른 사람을 위해서 헌신하며 사는 것에 실패함
→ 그러나 그들은 적어도 평
2. 질병의 기술
추간판탈출증 [Lumbar intervertebral disc]
교과서 자료
대상자자료
정의
추간판탈출증이란 척추뼈 사이에 위치한 물렁뼈조직이 나이가 듦에 따라 점점 딱딱하게 변성되고 이때 허리에 압박이 가해질때 과도한 하중으로 삐져나와 주위 신경을 눌러 생기는 질환이다.
원인
허